Parp Inhibitor Adverse Effects

Common side effects of parp inhibitors include.

Parp inhibitor adverse effects.

Upper respiratory tract infection anemia decreased hemoglobin increased mcv increased serum creatinine nasopharyngitis nausea pharyngitis vomiting cough and dyspnea. Some people who have ovarian cancer or breast cancer and who have received previous treatment with chemotherapy radiotherapy or certain other medicines for their cancer have developed mds or aml. Providers should be aware of the potential risk for gi toxicity with parp inhibitors. Parp inhibitors can affect blood cells and the most common serious side effects of niraparib were lower than normal levels of red blood cells anemia platelets thrombocytopenia and white blood cells neutropenia.

Findings from the prima trial were published september 28 in the new england journal of medicine. Lynparza may cause serious side effects including. See below for a comprehensive list of adverse effects. Some side effects of niraparib may occur that usually do not need medical attention.

The most common side effects associated with parp inhibitors are nausea vomiting and fatigue. Also your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Parp inhibitors are a group of pharmacological inhibitors of the enzyme poly adp ribose polymerase parp. Targeted therapies such as poly adp ribose polymerase parp inhibitors have emerged as one of the most exciting new treatments for ovarian cancer particularly in women with brca1 or brca2 mutations or those without a functional homologous recombination repair pathway.

The common side effects for all parp inhibitors can include. Common parp inhibitor side effects. You might be able to have medicines to help control them. These side effects may go away during treatment as your body adjusts to the medicine.

Regardless of which type all parp inhibitors share possible common side effects. They are developed for multiple indications including the treatment of heritable cancers. Side effects not requiring immediate medical attention. Lastly additional gi adverse effects that should be monitored with parp inhibitor use include constipation diarrhea abdominal pain dyspepsia dysgeusia and decreased appetite 2 5 conclusion.

All treatments can cause side effects. Bone marrow problems called myelodysplastic syndrome mds or acute myeloid leukemia aml. Generally speaking though most women can continue to go about their daily lives while taking these drugs. Several forms of cancer are more dependent on parp than regular cells making parp parp1 parp2 etc an attractive target for cancer therapy parp inhibitors appear to improve progression free.

Ovarian cancer remains one of the most challenging malignancies to treat. Side effects requiring immediate medical attention. The most common side effects associated with parp inhibitors are nausea vomiting and fatigue. Generally speaking though most women can continue to go about their daily lives while taking.

Tell your doctor or nurse if you have any of these side effects.