P53 Status Of Breast Cancer Cell Lines

Head and neck cancer cell lines.

P53 status of breast cancer cell lines.

Strikingly we found discrepancies in the p53 status for 23 88 384 of cell lines for which the p53 status was established independently in two laboratories. Wild type p53 was found in six cell lines and various p53 aberrations in the remaining twenty. Normal base sequence of the codon in which the mutation occurred. Tp53 codes for a transcription factor p53 that initiates transcription of genes involved in cell cycle arrest cellular senescence apoptosis metabolism dna repair and other processes following cellular stress.

This is a list of major breast cancer cell lines that are primarily used in breast cancer. Experiments using cell culture are used for developing new diagnostic tests and new treatments for diseases. Fasay detected temperature sensitive p53 mutations in breast cancer cell line bt474 and leiomyosarcoma cell line sk lms 1 and two independent p53 point mutations in sk ut 1 and sk lms 1 leiomyosarcoma cell lines. Germ line mutations in p53 occur in a high proportion of individuals with the li fraumeni cancer susceptibility syndrome which confers an increased risk of breast cancer this implies an important role for p53 inactivation in mammary carcinogenesis and the structure and expression of p53 has been widely studied in breast cancer.

Bladder cancer cell lines. Mut sequence of the mutated codon. Breast cancer cell lines. Nsclc cancer cell lines.

P53 mutation in breast cancer. Cell lines with a controversial p53 status. Codon position 1 to 393. Scientists study the behaviour of isolated cells grown in the laboratory for insights into how cells function in the body in health and disease.

The nci 60 panel. Colorectal cancer cell lines. Tp53 is the most frequently mutated gene in cancer including breast cancer. Esophageal cancer cell lines.

Most cell lines were established in late 1970s. Using the nci 60 cell line panel as a model widely used in the literature the p53 status could not be ascertained for 13 cell lines due to a lack of homogeneous data in the literature. Gastric cancer cell lines. Brain cancer cell lines.

Leukemia lymphoma cell lines. P53 activity is modulated by numerous posttranslational modifications association with protein. Cell lines with p53 mutations missense or frameshift more information is available in the handbook. If the mutation is a deletion or an insertion it is indicated by del or ins followed by the number of deleted or inserted bases.

Knowledgebase and statistical tools for the analysis of tp53 gene mutations in human cancers.